Neuroscience PreTest Self-Assessment and Review, Sixth by Allan Siegel

By Allan Siegel

I bought this article to arrange for the NBME shelf examination in neuroscience. whereas the textual content does a good task emphasizing different point of CNS neuroscience, it truly is week at the PNS that's largely verified at the shelf examination. additionally, there is not any psychopathology or neuropathology, subject matters that are additionally proven at the NBME shelf. for this reason, you will want extra research fabric for these subject matters. differently, a good textual content. it may possibly end up extra priceless for the step 1.

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Extra info for Neuroscience PreTest Self-Assessment and Review, Sixth Edition (PreTest Basic Science)

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Reproduced, with permission, from Kandel E: Principles of Neural Science, 4e. ) High-Yield Facts 37 Lateral spinothalamic tract. Mediates pain and temperature inputs contralaterally to the VPL and posterior complex of the thalamic nuclei and then to the postcentral gyrus. (Fig. 7) Anterior spinothalamic tract. Mediates tactile impulses contralaterally to the VPL and then to the postcentral gyrus. Posterior spinocerebellar tract. Mediates unconscious proprioception from muscle spindles and Golgi tendon organs of the lower limbs through the inferior cerebellar peduncle ipsilaterally to the anterior lobe of the cerebellar cortex.

Such a pathway has been identified at gap junctions. 2. Current generated by voltage-gated channels at the presynaptic neuron flows directly into the postsynaptic neuron. 1 ms). 3. Electrical transmission is not very common in the CNS. B. Characteristics of chemical transmission 1. At chemical synapses, the pre- and postsynaptic cells are separated by synaptic clefts, which are fluid-filled gaps (about 20 to 40 nm). The presynaptic terminal contains synaptic vesicles, which are filled with several thousand molecules of a specific chemical substance, the neurotransmitter.

Many varicosities (swellings), called synaptic boutons, are present at the terminals of these branches. The presynaptic boutons contain the synaptic vesicles containing acetylcholine. When the motor axon is stimulated, an action potential reaches the axon terminal and depolarizes the membrane of the presynaptic bouton, which results in the opening of the voltage-gated Ca2+ channels. Influx of Ca2+ into the terminal promotes fusion of the vesicle with the terminal membrane and subsequent release of acetylcholine by exocytosis.

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