By Andrea Lania, Anna Spada, Giovanni Lasio
This booklet presents up to date assurance of the main proper themes within the analysis and administration of craniopharyngiomas. After introductory dialogue of typical heritage and medical presentation, person chapters are dedicated to pathological and molecular elements, use of diagnostic imaging suggestions, the surgical method of craniopharyngiomas, radiotherapy and radiosurgery, and linked endocrine disturbances. a selected characteristic of the ebook is the precise realization dedicated to the metabolic outcomes of the sickness and comparable remedies, together with weight problems and electrolyte disturbances, and to cognitive changes. This publication could be of price to oncologists, neurosurgeons, and endocrinologists via supporting in diagnostic workup, supply of applicable therapy, and administration of the intense metabolic and endocrine consequences.
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Additional resources for Diagnosis and Management of Craniopharyngiomas: Key Current Topics
A Sox2-CreERT2 mouse line was used to simultaneously express oncogenic β-catenin and YFP in Sox2+ve cells in the adult pituitary, which resulted in tumour formation (Andoniadou et al. 2012). These tumours were undifferentiated and did not express synaptophysin, a characteristic common with human ACP. Unexpectedly, however, the tumours were not YFP+ve, indicating that tumour cells were not the progeny of the mutated Sox2+ve stem cells. Further analyses revealed that Sox2+ve cells proliferated transiently and stop proliferating, giving rise to clusters with nuclear–cytoplasmic β-catenin accumulation that were similar to the typical clusters observed in human ACP.
1999) suggested a cut-off of 7 %, but their proposal has not been validated by subsequent studies. The uneven distribution of positive cells is a factor that affects the 2 Craniopharyngioma: Pathological and Molecular Aspects 23 correlation with outcomes, particularly when small tissue is available. Nevertheless, in clinical practice and when dealing with single cases, a high Ki-67 in the primary tumour should be taken into consideration as possible indicator of a more aggressive behaviour and tendency to rapidly recur (Prieto et al.
More recently, Finzi et al. (2014) reported on a mixed ACP and silent ACTH macroadenoma in a 75-year-old woman presented with diplopia due to a sixth left nerve palsy. The ACP component was multiple foci of transition between CP and adenoma. ACP cells did not show any neuroendocrine markers or hormones, but rare adenomatous cells showed nuclear p40 immunoreactivity suggesting a divergent differentiation from the CP (Fig. 9). The adenoma cells showed intense and complete membranous immunoreactivity for β-catenin, whilst expression was weaker and often incomplete in ACP cells.