By Constantin A. Bona, Jean-Pierre Revillard
The sector of cytokine examine is increasing at a swift speed Contributions from the most important major teams on the earth at the constitution and organic homes of cytokine and cytokine receptors, in addition to built-in reports on cytokines in a number of physiological and pathological stipulations have been awarded in 3 problems with foreign studies of Immunology This choice of articles supplied a distinct resource of knowledge despite the fact that, vital discoveries are rising very speedily and a few of the studies written in 1997 are already superseded during this booklet, the editors gather experiences which have been up to date via their authors to incorporate all of the contemporary guides and unpublished information from the authors' laboratories This quantity may still function a great reference resource for all these involved via the a number of faces of cytokines in easy examine and within the health facility
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Extra resources for Cytokines and cytokine receptors : physiology and pathological disorders
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Our initial clinical trial involves the use of an antibody to IL-2Rβ (Mikβ1) that is shared by IL-2 and IL-15 for the therapy of patients with T-cell type large granular lymphocytic leukemia associated with hematocytopenias. The monoclonal large granular lymphocytes in this disease express IL-2Rβ and γc but not IL-2Rα [87,88]. Additional efforts are directed toward developing an inhibitor of JAK-3 as an agent for controlled immunosuppression. JAK-3 expression is limited largely to lymphocytes and hematopoietic cells.
Nature 270:153–157, 1994. 52. J. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc. Natl Acad. Sci. USA 92:8705–8709, 1995. 53. Miyazaki, T. , and Taniguchi, T. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc and lck cooperate in hematopoietic cell proliferation. Cell 81:223–231, 1995. 54. J. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.