By Susanne Grässel, Attila Aszódi
In 3 Volumes this mini ebook sequence offers present wisdom and new views on cartilage as a really good but flexible tissue. This moment quantity is devoted to uncomplicated pathologies of the 2 commonest osteoarticular illnesses affecting huge segments of the Western inhabitants, osteoarthritis and chondrodysplasias. This booklet addresses Professors, researchers and PhD scholars who're attracted to musculoskeletal and cartilage biology and pathobiology.
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Extra resources for Cartilage: Volume 2: Pathophysiology
Arthritis Rheum 52(8):2386–2395. 21215 Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A 111(47):E5114–E5122. 1414298111 Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M, Thompson EW (2009) Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.
Curr Drug Targets 11(5):599–613 Matthews GL, Hunter DJ (2011) Emerging drugs for osteoarthritis. Expert Opin Emerg Drugs 16(3):479–491. 576670 Mayan MD, Gago-Fuentes R, Carpintero-Fernandez P, Fernandez-Puente P, Filgueira-Fernandez P, Goyanes N, Valiunas V, Brink PR, Goldberg GS, Blanco FJ (2015) Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis. Ann Rheum Dis 74(1):275–284. 1136/annrheumdis-2013-204244 Messent EA, Ward RJ, Tonkin CJ, Buckland-Wright C (2007) Osteophytes, juxta-articular radiolucencies and cancellous bone changes in the proximal tibia of patients with knee osteoarthritis.
2 rticular Cartilage: Structure and Mechano-Sensing A Function The articular cartilage is a paucicellular type II collagen- and proteoglycan-rich tissue. It is a highly lubricated connective tissue with exceptionally low surface friction that allows smooth articulation of the opposing joint surfaces. Lubrication is achieved by a synergistic relationship between the proteoglycan, the lubricin and the glycosaminoglycan hyaluronan, together with phosphatidylcholine lipids (Seror et al. 2015). Intact lubrication protects the surface from shear stress.