Cardiac regeneration and repair: Biomaterials and tissue by Ren-Ke Li, Richard D. Weisel

By Ren-Ke Li, Richard D. Weisel

Cardiac Regeneration and service, quantity reviews using biomaterials, on my own or mixed with mobile remedy, in delivering tissue-engineered constructs to fix the injured middle and forestall or opposite middle failure.

Part one explores the diversity of biomaterials to be had for cardiac fix, together with nanomaterials and hydrogels. extra chapters discover using biomaterials to reinforce stem mobilephone treatment for restoring ventricular functionality and producing stem cell-modified intravascular stents. half makes a speciality of tissue engineering for cardiac fix, together with chapters on decellularized biologic scaffolds, artificial scaffolds, phone sheet engineering, maturation of sensible cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro purposes, and medical concerns for cardiac tissue engineering. eventually, half 3 explores vascular home improvement, together with chapters highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.

Cardiac Regeneration and service, quantity Two is complemented via an preliminary quantity overlaying pathology and remedies. jointly, the 2 volumes of Cardiac Regeneration and service provide a accomplished source for clinicians, scientists, or academicians occupied with cardiac regeneration, together with these attracted to telephone treatment, tissue engineering, or biomaterials.

  • Surveys the diversity of biomaterials on hand for cardiac fix, together with nanomaterials and hydrogels.
  • Focuses on tissue engineering for cardiac fix together with medical issues for cardiac tissue engineering
  • Explores vascular home improvement, highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels

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Extra info for Cardiac regeneration and repair: Biomaterials and tissue engineering

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Histologically, the degradable hydrogels elicited a stronger inflammatory response, perhaps through the release of degradation products. Similar to the previous study, both non-degradable hydrogels were able to increase infarct thickness; however, only the slowly Hydrogels for cardiac repair 25 degraded high HeMA-HA was able to increase thickness and only the apical infarct, possibly corresponding to the presence of the hydrogel. In terms of LV geometry, only the stiffer non-degradable hydrogel was able to significantly reduce change in end systolic volume.

Besides promoting electrical integrity, gold nanowires are also more suitable for mechanical reinforcement in the composite scaffolds, because nanowire as a continuum can sustain higher compression, tension and shear stresses than particles by offering more contact surface area between nanowires and polymeric scaffolds. Mechanical strength is a key to successful ECT because of the periodic stretching and compressing nature of cardiac muscles. Tissues grown on these composite matrices were thicker and better aligned than those grown on pristine alginate, and when electrically stimulated the cells in these tissues contracted synchronously.

Biodegradable microparticles and fiber fabrics for sustained delivery of cisplatin to treat C6 glioma in vitro. J Biomed Mater Res Part A. 85A:897–908. 15. Huebsch N, and Mooney DJ (2009). Inspiration and application in the evolution of biomaterials. Nature. 462:426–32. 16. Chew SY, Mi RF, Hoke A, and Leong KW (2007). Aligned protein–polymer composite fibers enhance nerve regeneration: a potential tissue-engineering platform. Adv Funct Mater. 17:1288–96. 17. Luong-Van E, Grondahl L, Chua KN, Leong KW, Nurcombe V, and Cool SM (2006).

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