By Rick Ng(auth.)
"Concise and simple to learn, the ebook fast introduces uncomplicated innovations, then strikes directly to talk about goal choice and the drug discovery strategy for either small and big molecular drugs."
—Doody's Reviews, may perhaps 2009
"The moment variation of a ebook that gives a effortless step by step advent to the entire key strategies all for bringing a drug to the industry, together with the functionality of preclinical trials."
—Chemistry World, February 2009
the recent version of this best-selling e-book maintains to provide a ordinary, step by step creation to the entire key methods excited about bringing a drug to the marketplace, together with the functionality of pre-clinical reviews, the behavior of human scientific trials, regulatory controls, or even the producing methods for pharmaceutical items. Concise and simple to learn, the ebook speedy introduces uncomplicated strategies, then strikes directly to talk about objective choice and the drug discovery procedure for either small and big molecular medications.
This moment version positive factors many key improvements, together with Key issues, bankruptcy precis, and evaluate Questions in each one bankruptcy, solutions to study Questions supplied in a book-end appendix, and one or rigorously chosen "mini" case stories in each one bankruptcy.
Richly illustrated all through with over 90 figures and tables, this significant booklet additionally contains worthy listings of present FDA and eu guidance and a distinct part on regulatory authority and strategies in China. it's an integral source for pharmaceutical and educational researchers, pharmaceutical managers and bosses, healthcare clinicians, policymakers, regulators, and lobbyists with an curiosity in drug improvement. it's also a great textbook for college students in pharmacy, technology, and drugs courses.Content:
Chapter 1 creation (pages 1–18):
Chapter 2 Drug Discovery: objectives and Receptors (pages 19–52):
Chapter three Drug Discovery: Small Molecule medicines (pages 53–92):
Chapter four Drug Discovery: huge Molecule medications (pages 93–135):
Chapter five Drug improvement and Preclinical reports (pages 136–175):
Chapter 6 medical Trials (pages 176–207):
Chapter 7 Regulatory gurus (pages 208–230):
Chapter eight Regulatory purposes (pages 231–277):
Chapter nine reliable production perform: Regulatory requisites (pages 278–318):
Chapter 10 stable production perform: Drug production (pages 319–358):
Chapter eleven destiny views (pages 359–390):
Read or Download Drugs: From Discovery to Approval, Second Edition PDF
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Extra info for Drugs: From Discovery to Approval, Second Edition
This involves using data on three-dimensional (3D) protein structure, coupled with knowledge of the physicochemical properties of amino acids, to determine if the amino acid sequence is likely to fold in the same way as a sequence for which the structure is known. In this way, more information about the putative target protein can be assessed. 4 TARGET VALIDATION Once a potential disease-causing target has been identified, a process of validation is carried out to confirm the functions and effects of the target.
The current method of drug discovery commences with the study of how the body functions, in both normal and abnormal cases afflicted with diseases. The aim is to break down the disease process into cellular and molecular levels. An understanding of the status of genes and their associated proteins would help to pinpoint the cause of the disease. Drugs can be tailor-made to attack the “epicenter” of diseases. 2) drugs can be discovered and manufactured to intervene or restore the cellular or molecular dysfunction.
Thomson Brooks/Cole, Belmont, CA, 2006. Campbell NA, Reece JB, Mitchell LG. , Benjamin/Cummings, Menlo Park, CA, 1999. Deller MC, Jones EY. Cell surface receptors, Current Opinion in Structural Biology 10:213–219 (2000). Dowell SJ. Understanding GPCRs—from orphan receptors to novel drugs, Drug Discovery Today 6:884–886 (2002). Ezzell C. Beyond the human genome, Scientific American July:64–69 (2000). 52 DRUG DISCOVERY: TARGETS AND RECEPTORS Foreman JC, Johansen T, eds. Textbook of Receptor Pharmacology, CRC Press, Boca Raton, FL, 2002.