Brain Metastases by Jeffrey J. Raizer, Lauren E. Abrey

By Jeffrey J. Raizer, Lauren E. Abrey

Mind metastases are the main dreaded difficulty of systemic melanoma, affecting nearly 170,000 humans a yr, a much better prevalence than fundamental mind tumors. Advances in smooth chemotherapy have resulted in a higher regulate of procedure cancers, frequently with brokers that poorly penetrate the primary frightened approach, leading to an expanding prevalence of mind metastases. conventional chemotherapy has had little impression on mind metastases. the most healing choice is radiation treatment, and in a small variety of sufferers - surgical procedure. despite the fact that, refinements in all of those remedies provide a few confident results and an elevated skill to stratify sufferers in response to sure criteria.
This booklet will deliver present details at the presentation and administration of sufferers with mind metastases, supplying to be had information, giving guidance that may be utilized in daily perform, up-to-date info for neuro-surgeons, radiation oncologists, clinical oncologists, and neuro-oncologists, in addition to an summary for physicians in education.

Show description

Read or Download Brain Metastases PDF

Similar neurosurgery books

Advanced Peripheral Nerve Surgery and Minimal Invasive Spinal Surgery

The papers during this quantity summarize information regarding the latest and powerful recommendations for treating diffcult practical difficulties and painful events through the use of minimally invasive spinal surgical procedure innovations. Spinal endoscopy either for diagnostic and therapy reasons is gifted in addition to microsurgical operations for spinal difficulties, intradiscal thoughts for the remedy of disc degenerative pathology, and dynamic stabilization innovations including an up to date assessment of physiopathology of the ailments.

Spinal Trauma Imaging, Diagnosis and Management

Written via well-known specialists, this quantity is a finished reference at the use of complicated imaging options within the analysis and administration of spinal trauma. in a single cohesive resource, the e-book brings jointly info on cutting-edge scientific imaging—including multidetector CT and high-field MRI techniques—and the pathophysiology, neurologic assessment, scientific administration, surgical operation, and postoperative evaluate of backbone trauma and spinal wire damage.

Principles of Neurosurgery

Nice e-book for the first yr resident and 4th yr scientific scholar. Many radiographs, charts, tables, surgical line drawings, and reliable references all through this textbook. it really is a chic hardcover ca 1999 with huge print, for that reason more straightforward to learn at midnight on-call rooms. i am hoping Drs. Loftus and Grossman choose to pop out with a third variation quickly.

Additional info for Brain Metastases

Example text

Important prognostic features include absence of extracranial disease progression, young age, high pretreatment neurological status, a low number of lesions, and a long interval from primary disease diagnosis to the development of brain metastases. The need to aggressively treat brain metastases effectively is becoming increasingly important, however, as treatment of systemic disease improves and an increasing number of patients are developing brain metastases in the setting of limited systemic disease.

J Clin Oncol 2001; 19(4):1207–1225. 88. McDonald DM, Baluk P: Significance of blood vessel leakiness in cancer. Cancer Res 2002; 62(18):5381–5385. 89. Bergers G, Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3(6):401–410. 90. Joyce JA: Therapeutic targeting of the tumor microenvironment. Cancer Cell 2005; 7(6):513–520. 91. He BP, Wang JJ, Zhang X, et al: Differential reactions of microglia to brain metastasis of lung cancer. Mol Med 2006; 12(7–8):161–170. 92. Klein CA, Blankenstein TJ, Schmidt-Kittler O, et al: Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer.

In addition to HSRT, whole brain radiotherapy up to a dose of 30 Gy was administered to all patients. [6] This study collected data from 32 patients treated with HSRT who had 57 brain metastases. The median dose was 3 fractions of 9 Gy for a total of 27 Gy. There was no significant acute toxicity observed, but four patients experienced seizures as late toxicities, while two patients has radionecrosis. [6] Therefore, the authors concluded that HSRT treatment is a feasible treatment option for brain metastases, and not only malignant primary brain tumors, because it was relatively well tolerated by Table 1.

Download PDF sample

Rated 4.06 of 5 – based on 39 votes