By Jeffrey J. Raizer, Lauren E. Abrey
Mind metastases are the main dreaded difficulty of systemic melanoma, affecting nearly 170,000 humans a yr, a much better prevalence than fundamental mind tumors. Advances in smooth chemotherapy have resulted in a higher regulate of procedure cancers, frequently with brokers that poorly penetrate the primary frightened approach, leading to an expanding prevalence of mind metastases. conventional chemotherapy has had little impression on mind metastases. the most healing choice is radiation treatment, and in a small variety of sufferers - surgical procedure. despite the fact that, refinements in all of those remedies provide a few confident results and an elevated skill to stratify sufferers in response to sure criteria.
This booklet will deliver present details at the presentation and administration of sufferers with mind metastases, supplying to be had information, giving guidance that may be utilized in daily perform, up-to-date info for neuro-surgeons, radiation oncologists, clinical oncologists, and neuro-oncologists, in addition to an summary for physicians in education.
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Additional info for Brain Metastases
Important prognostic features include absence of extracranial disease progression, young age, high pretreatment neurological status, a low number of lesions, and a long interval from primary disease diagnosis to the development of brain metastases. The need to aggressively treat brain metastases effectively is becoming increasingly important, however, as treatment of systemic disease improves and an increasing number of patients are developing brain metastases in the setting of limited systemic disease.
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In addition to HSRT, whole brain radiotherapy up to a dose of 30 Gy was administered to all patients.  This study collected data from 32 patients treated with HSRT who had 57 brain metastases. The median dose was 3 fractions of 9 Gy for a total of 27 Gy. There was no significant acute toxicity observed, but four patients experienced seizures as late toxicities, while two patients has radionecrosis.  Therefore, the authors concluded that HSRT treatment is a feasible treatment option for brain metastases, and not only malignant primary brain tumors, because it was relatively well tolerated by Table 1.