Brain diseases and metalloproteins by David R. Brown

By David R. Brown

This e-book describes the newest learn on neurodegenerative sickness and metal-binding proteins. It lays powerful emphasis on biochemistry and mobile biology. The illnesses coated within the e-book comprise Parkinson's affliction, Alzheimer's ailment, prion ailment, and ALS. The chapters individually research such matters as mechanisms of steel binding, metal-induced structural alterations in proteins, changes in mobile steel metabolism in affliction, and makes an attempt at a healing strategy in response to protein steel binding.

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Atwood, C. , Hartshorn, M. , Tyndall, J. D. , Hanson, G. , Stokes, K. , Goldstein, L. , Scarpa, R. , Saunders, A. , Moir, R. , Bowden, E. , Masters, C. , Fairlie, D. , Tanzi, R. E. and Bush, A. I. indd 27 6/20/2012 11:15:27 AM 28 A Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers cell-free hydrogen peroxide production and metal reduction. J. Biol. Chem. 274, pp. 37111–37116. , Riess, O. and Gasser, T. (2005) The role of α-synuclein gene multiplications in early-onset Parkinson’s disease and dementia with Lewy bodies.

The last considerations make it evident that Kd can give only an unfocused picture of the metal-protein interactions since it is unable to account for all the species formed in the system. As a consequence, the species really active in vivo could be unrecognized if they are formed in low fraction. On the other hand, this procedure is valuable to give a general description of the behaviour of highmolecular-weight substrates containing a high number of acidic or basic groups and of potentially donor atoms.

4, pp. 49–60. indd 30 6/20/2012 11:15:28 AM References 31 St. George-Hyslop, P. H. (2000) Molecular genetics of Alzheimer’s disease. Biol. Psychiat. 47, pp. 183–199. Tabner, B. , El-Agnaf, O. M. A. and Allsop, D. (2001) Production of reactive oxygen species from aggregating proteins implicated in Alzheimer’s disease, Parkinson’s disease and other neurodegenerative diseases. Curr. Top. Med. Chem. 1, pp. 507–517. Tabner, B. , El-Agnaf, O. M. A. and Allsop, D. (2002) Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease.

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