Bioinspired Approaches for Human-Centric Technologies by Roberto Cingolani

By Roberto Cingolani

The current publication discusses subject matters on the topic of study and improvement of fabrics and units at nanoscale measurement and their respective software in drugs and biomedicine.

The person chapters provide a close state-of-the-art evaluation to the particular subject. it appears disconnected fields - lifestyles sciences, biomedicine, chemistry, physics, medication and engineering - could be bridged with a hugely interdisciplinary view onto every one subject.

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The nanoparticles were injected either intratumorally or in the tail vein in a bladder cancer mouse model. In both cases, the combination of hyperthermia and synchronized local chemotherapy was more effective in cancer regression than the individual treatment. 3 MHz radio frequencies and 33 kA/m magnetic field) to activate the thermal response were out of the clinical relevance range for patients. For application on humans, lower radio frequencies (within the range 80–200 KHz and maximum 30 KA/m) need to be used to prevent deleterious side effects, and therefore new nanoparticle formulations with optimal heating performance have to be prepared.

Quarta et al. surface is generally weak, leading to nanoparticle aggregation with time. Recently, however, cross-linked ligand shells have been developed to improve nanoparticle stability in water (Dubertret et al. 2002; Jiang et al. 2008). Furthermore, the specificity of the ligand units toward the different materials, of which the nanoparticles are composed, implies that different ligands are required for different types of nanoparticles. Therefore, besides its simplicity, the ligand exchange procedure cannot be considered a method of general applicability.

Fig. 2 Scheme of the possible binding strategies for the attachment of antibodies to the nanoparticle surface. (a) The physical adsorption, (b) the covalent linkage, and (c) the use of adapter biomolecules should be well pondered. Usually, while the choice of the functional group on the antibody to be used for the binding to the nanoparticle is more restricted, due to the risk to compromise the binding efficiency of the antibody toward the antigen, the introduction of the proper functional group on the nanoparticle is easier and allows more freedom in the design of the functionalized nanoparticles carrying the proper binding moieties.

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