By Hendra Hermawan
This ebook within the rising learn box of biomaterials covers biodegradable metals for biomedical functions. The booklet comprises major components the place every one of them contains 3 chapters. the 1st half introduces the readers to the sector of steel biomaterials, exposes the state-of-the-art of biodegradable metals, and divulges its program for cardiovascular implants. a few primary points to offer easy figuring out on metals for extra overview at the degradable ones is roofed in bankruptcy one. the second one bankruptcy introduces the concept that of biodegradable metals, it is cutting-edge and discuses a shifted paradigm from inert to bioactive, from corrosion immune to corrodible metals. The 3rd bankruptcy makes a speciality of the demanding situations and possibilities of utilizing biodegradable metals for cardiovascular functions. the second one half exposes an instance of biodegradable metals from its notion to functions the place an entire research on steel biodegradable stent is certain from fabrics layout, improvement, trying out until the implant fabrication. The forth bankruptcy unearths new alloys improvement dedicated for steel biodegradable stent in response to required standards derrived from medical wishes and present nondegradable stents houses. Degradation of the alloys in simulated arterial stipulations and its impact to cells are uncovered in bankruptcy 5. The either chapters are concluded with a benchmarking of a few newer researches on fabrics improvement and trying out for biodegradable stents. bankruptcy six finds the tranformation technique of the fabrics into stent prototypes the place a regular technique for making 316L stainless-steel stents used to be undefined. The publication is done by means of a standpoint at the use of biodegradable metals for biomedical purposes within the period of tissue engineering.
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Extra resources for Biodegradable Metals: From Concept to Applications
However, it can be improved by alloying and employing advanced processing techniques. For example, alloying Mg with Li can change the crystal structure from hexagonal to body centered cubic and produces a large increase in ductility. 7wt% Li showed 52 % elongation but in exchange, tensile strength dropped to 132 MPa (Sanschagrin et al. 1996). Alloying of Mg may be limited to few metals which are known to be tolerated in the human body, including Ca, Zn, Mn and a very small amount of rare earth elements such as Y and Zr (Song 2007).
Benestent study group. N Engl J Med 331:489–495 Serruys PW, Kutryk MJ, Ong AT (2006) Coronary-artery stents. N Engl J Med 354:483–495 Sigwart U, Puel J, Mirkovitch V, Joffre F, Kappenberger L (1987) Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N Engl J Med 316:701–706 Song G (2007) Control of biodegradation of biocompatible magnesium alloys. Corr Sci 49:1696–1701 Stack RS, Califf RM, Phillips HR, Pryor DB, Quigley PJ, Bauman RP, Tcheng JE, Greenfield JC Jr (1988) Interventional cardiac catheterization at Duke medical center.
It can be concluded that the mechanical and physical property of the developed Fe-Mn alloys are suitable for the development of biodegradable coronary stents. Recent works on Fe-based alloys have mostly contributed to the improvement of mechanical performance of the previously developed binary Fe-Mn alloys (Hermawan et al. 2010). 1 summarizes mechanical properties of Fe-based biodegradable metals providing more alternative alloys for biodegradable medical applications. Following the binary Fe-Mn alloy work (Hermawan et al.