Benzimidazoles and Congeneric Tricyclic Compounds: Part Two,

Content material:
Chapter 6 Condensed Bemimidazoles of style 6?5?5 (pages 1–255): G. Tennant
Chapter 7 Condensed Benzimidazoles of style 6?5?6 (pages 257–461): G. Tennant
Chapter eight Condensed Benzimidazoles of kind 6?5?7 and better Homologs (pages 463–503): M. F. G. Stevens
Chapter nine Condensed Benzimidazoles Bridged among N?1 and C?7 (pages 505–529): M. F. G. Stevens
Chapter 10 advertisement purposes of Benzimidazoles (pages 531–542): P. N. Preston

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Additional info for Benzimidazoles and Congeneric Tricyclic Compounds: Part Two, Volume 40

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P. 2 m m Hg. Purified by sublimation. ' Yield not quoted. 1. Fused Benzimidazoleswith No Additional Heteroatoms 21 the nucleus. 7). 54; R' = R3= R4= H, R2 = Me) stands in contrast to the isomer mixture obtained3' (cf. 57; R' = R5 = Me, R2 = R3 = R4 = H). This latter result casts some doubt on the specificity of the cyclization of electronically biased 5(6)-substituted benzimidazoles by preferential ring-closure at the nitrogen atom para to the substituent. p. 1. 70)]. Ring-closure Reactions of Other Heterocycles Substituent i n t e r a ~ t i o nin~ ~N-(orfho-substituted pheny1)pyrrolidines is a rich source of 2,3-dihydro- 1H-pyrrolo[1,2-a]benzimidazoles.

17q 65 65 73 73 73 71 71 - 71 73 30 67 73 73 Ref. 15. 34tJ 4. 62quin. k a 6 in pprn measured from TMS. Signals are sharp singlets unless otherwise specified as: d =doublet; t = triplet; q = quartet; quin. =quintet; dd = double doublet; m = multiplet. A = pyridine; B = CdCI,; C = CF,CO,D; D = D,O; E = (CD,),SO; F = CF,CO,H; G = CDCI,-(CD,),SO. 7 Hz. 'J=7Hz. fJ=9Hz. K J = 2and 9Hz. OCOMe. J = 2 Hz. ' CH,DC. ' J = 7 . 5 Hz. ' Hydrochloride. 5 Hz. 5 Hz. ' N(CH,), of C(5) substituent. " Chemical shift in ppm relative to HOD.

22). 63). 12. 112) - - C0,Me C0,Me C0,Me C0,Me C0,Me - - H COPh H C0,Me C0,Me C0,Et B D B C B A B A C A = methanol; B =ethanol; C = methanol+3 drops of 72% HCl0,aq; D = phosphate buffer (pH 8). 111) _. 51). 35). 29). 72). 7 1). 110) are typified by the presence of two or more intense absorption bands at relatively long wavelength consistent with the high degree of delocalization and aromatic character (see later) associated with these molecules. 12) in changing from neutral to acidic solution. NUCLEAR MAGNETIC RESONANCE SPEW.

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