Aspartic Proteinases: Retroviral and Cellular Enzymes by Tom L. Blundell, Kunchur Guruprasad, Armando Albert, Mark

By Tom L. Blundell, Kunchur Guruprasad, Armando Albert, Mark Williams (auth.), Michael N. G. James (eds.)

The VIIth overseas convention on Aspartic Proteinases was once held in Banff, Alberta, Canada, from October 22 to 27, 1996. The venue was once the Banff Centre within the Canadian Rockies, a surroundings renowned world wide for the scenic attractiveness and mountain grandeur. It used to be maybe presumptuous of the organizers to name this the 7th Aspartic Proteinase convention however it used to be felt that the assembly in 1982, geared up via Tom Blundell and John Kay, was once of a global stature and coated themes sufficiently large to represent a convention. therefore, there's a discontinuity in that the Gifu convention equipped via Prof. Kenji Takahashi was once the 5th foreign convention on Aspartic Proteinases. formally, there has now not been a 6th convention and if there's confusion, it's the results of my wish to realize the significance of the London assembly. Banffhosted 106 scientists from 14 diversified nations. there have been 26 invited converse­ ers one of the forty four oral displays of the 7 major periods. furthermore, there have been fifty three con­ tributed poster shows that spanned the entire variety of curiosity in aspartic proteinases.

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Extra resources for Aspartic Proteinases: Retroviral and Cellular Enzymes

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However, when the stability of the pIS intermediate was examined by pulse-chase, only the P3BE mutation was observed to significantly delay further cleavage of pIS compared to wild type (data not shown). Conversely, the CS2 mutation actually reduced NC-p15 stability. Thus, the basic RKK motif located between the zinc fingers is necessary for the up-regulation of p 15 cleavage upon interaction with RNA in vitro and in the virion. We further examined the effect of the P3BE mutation, and the loss of p 15 cleavage upregulation, on virion morphology.

1992). While the composition of Gag intermediates is well defined, less is known about the exact order of cleavage in cells, or the significance of sequential processing in virion maturation. , 1991; Sheng and Erickson-Viitanen, 1994). In this assay Gag is produced by translation of synthetic mRNA in a rabbit reticulocyte lysate and is mixed with recombinant viral protease. During the subsequent processing of Gag, transient intermediates and final products are generated that are similar to those observed in infected cells (Figures 4 and 5).

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