Antisense Therapeutics by M. Ian Phillips (auth.), M. Ian Phillips PhD, DSc (eds.)

By M. Ian Phillips (auth.), M. Ian Phillips PhD, DSc (eds.)

Announcement of the full sequencing of the human genome in April 2003 verified the presence of hundreds of thousands of objectives for antisense oligonucleotides and opened the right way to countless numbers of preclinical animal stories and a few 20 ongoing medical trials. during this moment version of Antisense Therapeutics, a group of major researchers and scientific scientists show the hot fact of antisense and RNA inhibition for treating a extensive diversity of illnesses. The authors convey how antisense oligonucleotides are being designed and studied on the subject of high blood pressure, numerous cancers, inflammatory bowel disorder, mind problems, the blood-brain barrier, and drug supply. Highlights contain RNA-based cures for lots of illnesses, up to date equipment and functions, and perception into the big strength to supply a brand new new release of gear.
hugely functional and ailment orientated, Antisense Therapeutics, moment version deals not just a primer for a brand new new release of drug discovery researchers, but additionally an illuminating exploration of the aptitude in exploiting RNA inhibition for novel human therapeutics.

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2, 216–223. 35. Taylor, M. M. and Samson, W. K. (2002) Ribozyme compromise of adrenomedullin mRNA reveals a physiological role in the regulation of water intake. Am. J. Physiol. 282, R1739–R1745. 36. , et al. (1989) Design of a RNA enzyme distinguishing a single base mutation in RNA. Nucleic Acids Res. 17, 7059–7071. 37. , and Ohtsuka, D. (1992) Ribozymes designed to inhibit transformation of NIH/3T3 cells by the activated c-Ha-ras gene. Gene 117, 179–184. 38. 38 Usman, N. and Blatt, L. M. (2000) Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics.

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The only randomized study in humans with c-myc antisense demonstrated no reduction in restenosis after stent implantation when arteries were pretreated with the drug (5). Recently introduced, AVI-4126 belongs to a family of molecules known as the phosphorodiamidate morpholino oligomers (PMOs). These oligomers comprise (dimethylamino) phosphinylideneoxy-linked morpholino subunits. The morpholino subunits contain a heterocyclic base recognition moiety of DNA (A, C, G, T) attached to a substituted morpholine ring system.

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