Adult & Pediatric Spine

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Unfortunately, despite decades of work, we still know all too little. Most of what we do clinically with corticosteroids is empirical. The absence of a full understanding of their mechanism of action has blocked the search for drugs with similar benefit but that lack their troublesome side effects. Nonetheless, this deficiency in our understanding of how steroids work does not detract from the tremendous impact that this class of drugs has had upon the care of patients with brain tumors since they were introduced for control of tumorinduced edema nearly 40 years ago.

Conn HO, Blitzer BL. Non-association of adrenocorticosteroid therapy and peptic ulcer. N Engl J Med 1976;294:473–479. 7. Conn HO, Poynard T. Andrenocorticosteroid administration and peptic ulcer: a critical analysis. J Chron Dis 1985;38:457–468. 8. Carson JL, Strom BL, Schinnar R, et al. The low risk of upper gastrointestinal bleeding in patients dispensed corticosteroids. Am J Med 1991;91:223–228. 9. Vick NA. Letter to the editor. J Neurooncol 1988;6:199. 10. Dropcho EJ, Soong SJ. Steroid-induced weakness in patients with primary brain tumors.

Indication for computed tomography of the brain in patients with first uncomplicated generalized seizure. BMJ 1994;309:986–989. 49. Hopkins A, Garman A, Clarke C. The first seizure in adult life: value of clinical features, electroencephalography, and computerized tomgraphic scanning in prediction of seizure recurrence. Lancet 1988;1:721–726. 50. Daras M, Tuchman AJ, Strobos RJ. Computed tomography in adult-onset epileptic seizures in a city hospital population. Epilepsia. 1987 Sep-Oct;28(5):519–522.

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